"Beautifully decorated rooms, cozy and comfortable beds."
Ann from United States
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"I loved the charm of the building, and Michael's homemade bread was delicious!"
Karla from United States
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"Love the tub with jets and themed rooms."
Venessa from United States
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"Refrigerator stocked with water and yogurt and a basket with granola bars and chip for snack."
Joseph from United States
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3-room historic bed and breakfast in an 1875 former bank building in downtown Hannibal
Accommodations
Main Street Bed & Breakfast offers three themed rooms on the second floor of an 1875 former bank building, each accessed by a winding staircase. The Renaissance Room, Deluxe Queen Suite, and other themed rooms feature high ceilings, king-sized or queen-sized beds, and large windows with city or Mississippi River views. Each room includes a spa bath or jetted tub for two, a flat-screen TV with streaming services, and a private bathroom with bathrobes.
Dining & Breakfast
Guests receive a daily continental breakfast stocked directly in the room, including homemade quick breads like pumpkin bread or chocolate chip bread from the owner Mike. The refrigerator contains bottled water, yogurt, and fruit cups, while a basket provides granola bars, snack bars, and additional snacks. Coffee and tea are prepared using the in-room coffee maker with half-and-half creamer provided.
Location & Nearby Attractions
The bed and breakfast sits on Main Street, one block from the Mississippi River and within walking distance to Mark Twain Boyhood Home and Museum. Guests can walk to the riverboat cruises, Bluff City Theater, and Big River Train Town, as well as the Brick Oven restaurant across the street. The building is also close to the Hannibal waterfront and downtown shops that close around 5 pm.
Amenities & Services
The hotel provides free private on-site parking and offers complimentary bike hire for guests to explore the surrounding area. Personalized guest interaction includes Michael greeting each arriving guest, providing local recommendations, and assisting with luggage up the 25 stairs. Free WiFi, a hot tub, BBQ facilities, and a keyless entry system are available, along with earplugs for the train noise one block away.
Activities & Entertainment
Guests can enjoy walking tours, pub crawls, and guided tours about local culture organized nearby. Evening entertainment and live sport events are offered within walking distance from the hotel. The property also provides access to a golf course, mini golf, and bike tours in the Hannibal area.
Highlights
Building: 1875 former bank with winding staircase and high ceilings
Rooms: Themed rooms with spa baths, jetted tubs for two, and Mississippi River views
Parking: Free private on-site parking, plus street parking available
Owner: Mike provides personal greetings, local recommendations, and luggage assistance
Location: 1 block from Mississippi River, walk to Mark Twain museums and riverboat cruises
“My stay at this inn was marked by thoughtful touches, from the well-appointed room featuring a jet tub and separate shower to the delicious homemade baked goods alongside plentiful refreshments. Its location proved exceptionally convenient for exploring the historic district on foot, with dining and shopping just a short walk away. I found the atmosphere authentically charming and felt very secure throughout my visit, making it a place I'd readily consider returning to.”
James DavidEditor-in-Chief at Usmissouri
Select your room type
Main Street Bed & Breakfast offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals
Deluxe Queen Suite
2 persons
37 sq. feet
1 King-size bed
Air conditioning
Bathtub
room details
Deluxe King Suite
2 persons
41 sq. feet
1 King-size bed
Air conditioning
Bathtub
room details
Price and Room Availability Calendar
Check availability and prices for your dates now!
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Check-in/ Check-out
Facilities
Main Street Bed & Breakfast offers amenities for your comfortable stay and unforgettable experiences
Facilities: Perfect
9.4/10Review score
General
No smoking on site
Wi-Fi
Parking
VIP check-in/ -out
Express check-in/ -out
Concierge desk
No pets allowed
Security
Adults only
Smoke detectors
Fire extinguishers
Key access
Sports & Fitness
Canoeing
Hiking
Cycling
Bowling
Golf course
Fishing
Services
Valet parking
Housekeeping
Tours/Ticket assistance
Dining
In-room breakfast
Special diet menus
Spa & Leisure
Aqua park
Live entertainment
Night club
BBQ facilities
Jacuzzi
Room features
Air conditioning
Heating
Soundproofed rooms
Sitting area
Garden furniture
Tea and coffee facilities
Bathroom
Free toiletries
Media
Flat-screen TV
AM/FM alarm clock
Room decor
Carpeted floor
Show more
Main Street Bed & Breakfast Location
201 North Main Street, Hannibal, 63401,
Explore Hannibal
Explore Hannibal
Top Attractions
Activities
Dining
Entertainment
Mark Twain Boyhood Home and Museum
5 minutes walking
This historic site showcases the home where Mark Twain lived as a boy, with guided tours available to enrich your visit.
Haunted House on Hill Street Wax Museum
3 minutes walking
Featuring life-like wax figures and spooky themes, this museum is a fun and unique attraction for all ages.
Rockcliffe Mansion
5 minutes drive
A stunning Victorian mansion offering guided tours, beautiful gardens, and picturesque views of the Mississippi River.
Mark Twain Statue
10 minutes drive
An iconic statue honoring the author, located near the river, providing great photo opportunities and historical context.
Hiking at Sodalis Nature Preserve
5 minutes drive
This nature preserve features scenic trails perfect for hiking, with wildlife viewing opportunities along the way.
Relaxation at Glascock's Landing
5 minutes walking
A serene spot by the river, ideal for picnicking or enjoying calming views, perfect for unwinding after a busy day.
The Brick Oven
1 minute walking
Offering delicious pizzas and Italian dishes, this cozy restaurant is perfect for casual dining with family and friends.
Finn's Food and Spirits
1 minute walking
Known for its diverse menu and local brews, Finn's features a laid-back atmosphere and hearty meals to satisfy any appetite.
Java Jive
1 minute walking
A local favorite coffee shop, offering live music and a vibrant atmosphere that makes it a great stop for evening relaxation.
Riverside Restaurant
2 minutes walking
This intimate dining spot often features live entertainment, ensuring a lively atmosphere alongside delicious cuisine.
Getting around
City Centre
Hannibal 5 min · 1400 ft
Airports
Quincy Regional (UIN) 68 min · 27.8 mi
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Property information and rules
Check-in
from 14:00-20:00
Check-out
from 06:00-11:00
Guest Parking
Private parking is possible on site for free.
Internet
Wireless internet is available in the entire hotel for free.
Breakfast
At the hotel Main Street Bed & Breakfast guests are invited to a full breakfast served for free.
Pets
Pets are not allowed.
Reviews and Ratings
Feedback about Main Street Bed & Breakfast from previous guests about their experience.
Review score
Based on 94 verified reviews
9.1 /10
Perfect
95 %
Recommend
Cleanliness
9.6/10
Comfort
9.5/10
Facilities
9.4/10
Free WiFi
8.5/10
Location
9.7/10
Staff
9.6/10
Value for money
9.1/10
Pros
Comfortable bed
Clean room
Jet bathtub
Homemade bread
Convenient location
Cons
Noise level
Street parking
Breakfast expectations
Window replacement
Guest reviews
based on 151 reviews
9.3/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
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